rip kinase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12728	RIP2 Kinase Inhibitor 3		Others , RIP kinase
	RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.		Others , RIP kinase
T3537	GSK583		RIP kinase
	GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).		RIP kinase
T7795	RIPA-56		RIP kinase
	RIPA-56 is an inhibitor of RIP1		RIP kinase
T9305	Necroptosis-IN-1		RIP kinase
	Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.		RIP kinase
T7151	GSK2982772		RIP kinase
	GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.		RIP kinase
T6815	HS-1371		RIP kinase
	HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.		RIP kinase
T9702	Eclitasertib		RIP kinase
	Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).		RIP kinase
T15437	GSK3145095		RIP kinase
	GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.		RIP kinase
T5054	GSK963	GSK963 (Racemate)	RIP kinase
	GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).		RIP kinase
T12493	PK68		Others , RIP kinase
	PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of inflammatory disorders and cancer metastasis.		Others , RIP kinase
T11501	GSK840	GSK'840	RIP kinase
	GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds the RIP3 kinase domain (IC50: 0.9 nM), and inhibits kinase activity (IC50: 0.3 nM).		RIP kinase
T11492	GSK2983559 free acid		Others , RIP kinase
	GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking many proinflammatory cytokine responses in human inflammato...		Others , RIP kinase
T6852	GSK481	GSK'481	RIP kinase
	GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.		RIP kinase
T7397	GSK547	GSK'547	RIP kinase
	GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.		RIP kinase
T12731	RIPK1-IN-7		RIP kinase
	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.		RIP kinase
T40187	GNF2133		DYRK
	GNF2133 is an effective and selective inhibitor of DYRK1A with IC50s of 6.2 nM. GNF2133 can be used in studies about type 1 diabetes.		DYRK
T1847	Necrostatin-1	Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO) , Ferroptosis , Autophagy , RIP kinase
	Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
T4074	GSK-872	GSK872,GSK'872,GSK2399872A	RIP kinase
	GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).		RIP kinase
T16753	RIP2 kinase inhibitor 2		Others
	RIP2 kinase inhibitor 2 is a receptor-interacting protein-2 kinase inhibitor.		Others
T12727	RIP2 kinase inhibitor 1		Others
	RIP2 kinase inhibitor 1 is a potent and selective receptor interacting inhibitor of protein 2 (RIP2) kinase(RIP2 FP with an IC50 of 0.03 μM ),and is used for autoinflammatory disorders.		Others